What is the definition of necrosis?

Necrosis is defined as complete tissue death and breakdown. This process occurs when cells in a certain area of the body die due to various factors, such as lack of blood supply, infection, or toxic exposure. When tissue undergoes necrosis, it typically loses its structural integrity and cellular function, leading to the breakdown of that tissue.

While other options touch upon aspects related to tissue health, they do not encompass the full scope of necrosis. For instance, while inadequate blood flow does contribute to tissue damage, it is merely one underlying cause rather than a definition of necrosis itself. Localized tissue perfusion problems can lead to necrosis but do not define the condition. Similarly, irreversible loss of cellular function may occur during necrosis, yet it does not capture the entirety of the process, which includes tissue death and disintegration. Thus, the most accurate and comprehensive understanding of necrosis is as complete tissue death and breakdown.